GPT-4o vs Mixtral 8x22B Instruct vs Mistral Large 2407

GPT-4o is the better all-round choice, scoring 43/100 against Mistral Large 2407 (39) and Mixtral 8x22B Instruct (34). It leads on capability and inputs & features. The score weighs capability 50%, price 25%, inputs & features 15%, context window 10%.

Mixtral 8x22B Instruct is cheaper at $2.00 input / $6.00 output per million tokens (median across 5 API providers). Mistral Large 2407 costs $2.00 input / $6.00 output per million tokens (median across 5 API providers); GPT-4o costs $2.50 input / $10.00 output per million tokens (official OpenAI API price). At a typical mix of three input tokens to one output token, that is $3.00 per million tokens for Mixtral 8x22B Instruct versus $3.00 for Mistral Large 2407 (1× as much) and $4.38 for GPT-4o (1.5× as much).

GPT-4o scores higher on the Capabilities Index (ECI): GPT-4o 129.0 (#141 of 165), Mistral Large 2407 127.6 (#144 of 165) and Mixtral 8x22B Instruct 122.0 (#155 of 165). The confidence ranges of the top two overlap (124.7–131.3 vs 123.3–129.4), so treat the gap as small. On individual benchmarks: GPQA Diamond — Mistral Large 2407 49.0%, GPT-4o 48.9%, Mixtral 8x22B Instruct 34.1%.

There are no published SWE-bench Verified results for GPT-4o, Mixtral 8x22B Instruct and Mistral Large 2407 yet, so there is no like-for-like coding score. On overall capability, GPT-4o leads, which tends to carry over to coding, but test on your own codebase. All three support tool calling for agent workflows.

Mistral Large 2407 has the largest context window at 131,072 tokens, against 128,000 for GPT-4o and 65,536 for Mixtral 8x22B Instruct. Maximum output per response: GPT-4o up to 16,384, Mixtral 8x22B Instruct up to 52,428, Mistral Large 2407 up to 104,857 tokens.

GPT-4o accepts text, images and PDFs; Mixtral 8x22B Instruct accepts text and PDFs; Mistral Large 2407 accepts text and PDFs. GPT-4o handles the widest range of inputs.

Mixtral 8x22B Instruct and Mistral Large 2407 publishes its weights and can be self-hosted; GPT-4o is proprietary.

Mistral Large 2407 is the newest, released Jul 24, 2024. GPT-4o came out May 13, 2024; Mixtral 8x22B Instruct came out Apr 17, 2024. Knowledge cutoff: GPT-4o Sep 2023, Mixtral 8x22B Instruct Jan 31, 2024, Mistral Large 2407 Mar 31, 2024.

Each model gets a 0–100 score on capability (50%, independent benchmark results); price (25%, blended price per million tokens (3 input : 1 output), log scale); inputs & features (15%, image, PDF, audio and video input, tool calling, structured output and reasoning); context window (10%, maximum tokens per request, log scale). Dimensions missing for any model are dropped and the remaining weights rescaled, so every model is judged on the same evidence. Specs and prices come from public model listings and the labs’ own API pages; capability scores come from independent benchmark runs. Data updated Nov 2, 2026.